Magnetic Nanoparticles Cross the Blood-Brain Barrier: When Physics Rises to a Challenge
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منابع مشابه
Magnetic Nanoparticles Cross the Blood-Brain Barrier: When Physics Rises to a Challenge
The blood-brain barrier is a physical and physiological barrier that protects the brain from toxic substances within the bloodstream and helps maintain brain homeostasis. It also represents the main obstacle in the treatment of many diseases of the central nervous system. Among the different approaches employed to overcome this barrier, the use of nanoparticles as a tool to enhance delivery of ...
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Delivery of therapeutic or diagnostic agents across an intact blood-brain barrier (BBB) remains a major challenge. Here we demonstrate in a mouse model that magnetic nanoparticles (MNPs) can cross the normal BBB when subjected to an external magnetic field. Following a systemic administration, an applied external magnetic field mediates the ability of MNPs to permeate the BBB and accumulate in ...
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ژورنال
عنوان ژورنال: Nanomaterials
سال: 2015
ISSN: 2079-4991
DOI: 10.3390/nano5042231